Inflammation and Immunity
The Keppler Lab is part of the Division of Rheumatology and Immunology at the Medical University of Graz and is dedicated to translational immunology at the interface of basic research and clinical practice. Our research focuses on cell–cell and cell–niche interactions, with particular emphasis on how tissue niches, metabolism, and immune cells interact in health and disease. Current and future research in the Keppler Lab is specifically aimed at elucidating the role of B cells and plasma cells as key modulators of inflammatory niches in autoimmune diseases.
To address these questions, we employ a broad range of experimental approaches, including in vitro culture systems of human and murine immune cells, adipocyte spheroid cultures, advanced co-culture systems, and preclinical models of autoimmune diseases. To investigate immune cell interactions during inflammation, we develop and apply state-of-the-art single-cell technologies such as advanced multicolor flow cytometry and mass cytometry (CyTOF). These approaches are complemented by modern imaging techniques, including whole-organ imaging using our EMOVI protocol and image cytometry.
In addition, we collaborate closely with physicists and microscopists to develop innovative methodologies that enable a more systemic and integrative analysis of autoimmune disorders.
For more details on our research projects, please visit our Research projects tab!
For more details on imaging please visit our Imaging tab!