a selection

Burbage M, Keppler SJ Shaping the humoral immune response: Actin regulators modulate antigen presentation and influence B-T interactions (2018). Mol Immunol. doi: 10.1016/j.molimm.2018.07.026

Keppler S.J., Burbage M., Gasparrini F., Hartjes L., Aggarwal S., Massaad M.J., Geha R.S., Bruckbauer A., Batista F.D. The lack of WIP binding to actin results in impaired B cell migration and altered humoral immune responses (2018). Cell Reports DOI 10.1016/j.celrep.2018.06.051.

Wartewig T, Kurgyis Z, Keppler S, Pechloff K, Hameister E, Öllinger R, Maresch R, Buch T, Steiger K, Winter C, Rad R, Ruland J. PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis. Nature. 2017 Dec 7;552(7683):121-125.

Burbage M, Keppler SJ, Montaner B, Mattila PK, Batista FD. The Small Rho GTPase TC10 Modulates B cell Immune Responses. J Immunol. 2017 Sep 1;199(5):1682-1695.

Martinez-Martin N, Maldonado P, Gasparrini F, Frederico B, Aggarwal S, Gaya M, Tsui C, Burbage M, Keppler SJ, Montaner B, Jefferies HB, Nair U, Zhao YG, Domart MC, Collinson L, Bruckbauer A, Tooze SA, Batista FD. A switch from canonical to non-canonical autophagy shapes B cell responses.  Science. 2017 Feb 10;355(6325):641-647.

Kühn J., Wong L.E., Pirkuliyeva S., Schulz K., Schwiegk C., Fünfgeld K.G., Keppler S., Batista F.D., Urlaub H., Habeck M., Becker S., Griesinger C., Wienands J. The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation. Science Signaling, 2015, Vol. 9 Issue 434 ra66

Keppler S.J., Gasparrini F., Burbage M., Aggarwal S., Frederico B., Geha R., Way M., Bruckbauer A., Batista F.D., Wiskott-Aldrich Syndrome Interacting Protein deficiency uncovers the role of the co-receptor CD19 as a generic hub for PI3K signaling in B cells. Immunity 2015 Oct 20;43(4):660-73

Burbage M., Keppler S.J., Gasparrini F., Martinez-Martin N., Gaya M., Feest C., Domart M.-C., Brakebusch C., Collinson L., Bruckbauer A., and Batista F.D. Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity. 2015,  Journal of Experimental Medicine, 212(1):53-72.

Keppler, S. J., Theil, K., Koegl, T., Vucikuja, S. and Aichele, P. Signal 3 cytokines as modulators of primary immune responses during infections: the interplay of type I IFN and IL-12 in CD8 T cell responses, 2012, PLoS One. 7(7):e40865

Keppler, S. J. and Aichele, P. Signal 3 requirement for memory CD8+ T-cell activation is determined by the infectious pathogen, 2011, European Journal of Immunology. 41, 3176 – 86

Keppler, S.J., Theil, K., Vucikuja, S. and Aichele, P. Effector T-cell differentiation during viral and bacterial infections: Role of direct IL-12 signals for cell fate decision of CD8 T cells, 2009, European Journal of Immunology. 39, 1774-83