B cells and Plasma Cells

as modulators of different immune niches

Current and future studies of the Keppler lab aim at elucidating the role of B cells and plasma cells as modulators of the inflammatory niche during autoimmunity. We are therefore investigating

(1) the role of the actin cytoskeleton in regulating B cell metabolism during TLR-mediated B cell responses;

(2) the plasticity and function of gut-derived plasma cells in different immune niches during homeostasis and inflammation;

(3) the influence of aberrant B cell activation and plasma cell formation on immune cell crosstalk in metabolic niches such as the lamina propria of the gut, or the mesenteric adipose tissue.

To achieve this, we combine state-of-the-art single-cell analysis (flow and mass cytometry, single-cell RNA sequencing and microscopy), as well as genetic tools to investigate the role of B cells as potential drivers of inflammation during homeostatic and inflammatory conditions. We furthermore established collaborations with physicists and microscopists to develop new approaches in order to achieve a more systemic analysis of autoimmune disorders.

More information on the different projects to follow soon!